Munster winger Simon Zebo has been selected at-full back in the Irish team to face Scotland this Saturday in their Rugby World Cup warm up, while Gordon D'Arcy plays as expected in the centre.
Leinster's Ian Madigan is also named at out-half with his provincial colleague Isacc Boss partnering him at scrum half.
In the forwards Jack Conan (23) makes his debut at blindside flanker, while Sean O'Brien starts at No 8 as captain.
There was also an update on the fitness of winger Andrew Trimble, who is nursing a foot injury:
Andrew Trimble has bruising on the foot and the toes, will resume running next week and should be fit for selection for Wales in 8 days time
— David McIntyre (@DaveMcIntyreNT) August 13, 2015
Overall Schmidt has made 14 changes to the team that beat Wales.
Mike Ross is the only survivor from the side that started last weekend's win over Wales as he continues his remarkable record of having played in every game under the head coach.
Schmidt has also revealed that Marty Moore could have played this weekend if necessary - but they decided not to risk his recovery from injury.
Moore and Tadhg Furlong are both likely to play in the pre-season friendly between Leinster and Ulster next week.
Meanwhile, New Zealand-born flanker Hugh Blake will make his debut for the Scots.
It had already been announced that Blake's Glasgow team-mate Henry Pyrgos will captain the side.
Here is the full Ireland XV for the match:
Here's the Ireland team to play @Scotlandteam in the Guinnes Summer Series on Saturday #ShoulderToShoulder pic.twitter.com/MFsrWHKikY
— Irish Rugby (@IrishRugby) August 13, 2015
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