The League Cup will play host to a Manchester derby as United and City were drawn together in the last-16.
Manchester United, who won 3-1 at Northampton in Wednesday night's third round tie, will host the EFL Cup fixture.
Holders City were 2-1 winners at Swansea this evening and won by the same scoreline when they faced United in the first derby of the season earlier this month.
Tottenham's 5-0 victory against Gillingham has earned them a trip to face Liverpool, with whom they drew this month in the league.
Meanwhile, West Ham's reward for their 1-0 victory over Accrington - via a 96th-minute goal - is a home tie against Chelsea.
Arsenal will host Reading in their tie.
EFL Cup last-16 draw
West Ham v Chelsea
Manchester United v Manchester City
Arsenal v Reading
Liverpool v Tottenham
Bristol City v Hull
Leeds v Norwich
Newcastle v Preston
Southampton v Sunderland
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