Wales head coach Wayne Pivac has made four changes to the team that was beaten by England last weekend for this Saturday's Guinness Six Nations clash against Scotland.
Scrum-half Rhys Webb makes his first start for his country in almost 2 and a half years, while uncapped Sale prop WillGriff John, front row Wyn Jones and lock Cory Hill also come into the side.
Captain Alun Wyn Jones will equal the world record for most international appearances when he play's in his 148th Test in Cardiff.
“You just need to speak to anybody that he plays against, they hold him in high record," Pivac said of Jones' landmark appearance.
“I’ve seen first hand what he does in training and our environment. His leadership off the field is huge. He’s the first guy at a drill in training every single time.
“He’s the ultimate professional. He is world class, there is no doubt about it. It will be a proud moment for him.”
Meanwhile, Scotland head coach Gregor Townsend has made three changes for their trip to Cardiff. Hooker and vice-captain Stuart McInally, number eight Magnus Bradbury and second-rower Sam Skinner come into the side.
Fraser Brown and Scott Cummings drop to the bench, with Nick Haining unavailable through illness.
Wales v Scotland: Leigh Halfpenny; George North, Nick Tompkins, Hadleigh Parkes, Liam Williams; Dan Biggar, Rhys Webb; Wyn Jones, Ken Owens, WillGriff John; Cory Hill, Alun Wyn Jones (C); Ross Moriarty, Justin Tipuric, Josh Navidi.
Replacements: Ryan Elias, Rhys Carre, Leon Brown, Will Rowlands, Taulupe Faletau, Gareth Davies, Jarrod Evans, Johnny McNicholl.
Scotland v Wales: Stuart Hogg (C); Sean Maitland, Chris Harris, Sam Johnson, Blair Kinghorn; Adam Hastings, Ali Price; Rory Sutherland, Stuart McInally, Zander Fagerson; Sam Skinner, Grant Gilchrist; Jamie Ritchie, Hamish Watson, Magnus Bradbury.
Replacements: Fraser Brown, Allan Dell, Willem Nel, Scott Cummings, Matt Fagerson, George Horne, Duncan Weir, Kyle Steyn.
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