Garry Ringrose and James Ryan will miss Ireland's final Six Nations game of the campaign.
Ryan was taken off in Sunday's 27-24 victory over Scotland for a head injury assessment. It was the Leinster lock's second blow to the head of the tournament, and he will sit out the visit of England to the Aviva Stadium.
Ringrose sustained an ankle injury, one which will be assessed by both the Ireland and Leinster medical teams. Leinster will hope the injury is not too serious with their Heineken Champions Cup last-16 meeting with Toulon just under three-weeks away.
Tom O'Toole is to remain with Ulster after picking up a knock at the end of last week.
Finlay Bealham will remain with the Ireland squad, with the Connacht prop having provided extra cover in the lead-in to Sunday's game at Murrayfield.
In better news for Andy Farrell and co, Peter O'Mahony is once again available having served his three-game ban for the red card received in the opening weekend defeat to Wales.
Ireland squad v England:
Backs
Bundee Aki (Connacht/Galwegians) 30 caps
Billy Burns (Ulster) 6 caps
Ross Byrne (Leinster/UCD) 12 caps
Craig Casey (Munster/Shannon) 1 cap
Andrew Conway (Munster/Garryowen) 24 caps
Keith Earls (Munster/Young Munster) 92 caps
Chris Farrell (Munster/Young Munster) 14 caps
Jamison Gibson Park (Leinster) 9 caps
Robbie Henshaw (Leinster/Buccaneers) 51 caps
Hugo Keenan (Leinster/UCD) 10 caps
Jordan Larmour (Leinster/St Mary’s College) 27 caps
James Lowe (Leinster) 6 caps
Stuart McCloskey (Ulster/Bangor) 4 caps
Conor Murray (Munster/Garryowen) 88 caps
Jonathan Sexton (Leinster/St Mary’s College) 98 caps
Jacob Stockdale (Ulster/Lurgan) 33 caps
Forwards
Ryan Baird (Leinster/Dublin University) 2 caps
Finlay Bealham (Connacht/Buccaneers) 14 caps
Tadhg Beirne (Munster/Lansdowne) 21 caps
Ed Byrne (Leinster/UCD) 4 caps
Jack Conan (Leinster/Old Belvedere) 19 caps
Will Connors (Leinster/UCD) 9 caps
Ultan Dillane (Connacht/Corinthians) 18 caps
Tadhg Furlong (Leinster/Clontarf) 48 caps
Cian Healy (Leinster/Clontarf) 108 caps
Dave Heffernan (Connacht/Buccaneers) 5 caps
Iain Henderson (Ulster/Academy) 62 caps
Rob Herring (Ulster/Ballynahinch) 20 caps
Ronan Kelleher (Leinster/Lansdowne) 10 caps
Dave Kilcoyne (Munster/UL Bohemians) 42 caps
Peter O’Mahony (Munster/Cork Constitution) 74 caps
Andrew Porter (Leinster/UCD) 35 caps
Rhys Ruddock (Leinster/St Mary’s College) 27 caps
CJ Stander (Munster/Shannon) 50 caps
Josh van der Flier (Leinster/UCD) 30 caps
Guardiola: Right now this is the worst City team I’ve managed
Download the brand new OffTheBall App in the Play Store & App Store right now! We've got you covered!
Subscribe to OffTheBall's YouTube channel for more videos, like us on Facebook or follow us on Twitter for the latest sporting news and content.
