Garry Ringrose, Keith Earls, Paddy Jackson and Iain Henderson have all been named in the Ireland team ahead of Saturday's final Autumn international.
Ringrose comes into the team in place of Rob Henshaw, to make his third appearance. Earls returns from injury, as Simon Zebo drops to the bench. Jackson starts at fly-half in place of the injury Jonny Sexton, while Henderson is picked instead of Donnacha Ryan.
Speaking at the team announcement, head coach Joe Schmidt said the Munster second-row was "fatigued" after playing in the opening three games of the Autumn campaign.
Here's your @IrishRugby to play @qantaswallabies #TeamOfUs #ShoulderToShoulder #GuinnessSeries pic.twitter.com/svTAaPRIkH
— Irish Rugby (@IrishRugby) November 24, 2016
Apart from those four changes, the team remains the same from the side that lost 21-9 to New Zealand last weekend. After being replaced in the first-half of the loss, CJ Stander has proven his fitness to start in the game.
On the bench, Ultan Dillane takes his place among the replacements and is joined by Joey Carberry, who will be expected to make his third appearance. Simon Zebo is the only other change to the replacements, swapping with Ringrose.
In the last ten years, Ireland and Australia have played on seven occasions, with both teams winning three times. They drew 20-20 in Croke Park in 2009.
Download the brand new OffTheBall App in the Play Store & App Store right now! We've got you covered!
Subscribe to OffTheBall's YouTube channel for more videos, like us on Facebook or follow us on Twitter for the latest sporting news and content.