Champions Dundalk got themselves off to a winning start last week against Shamrock Rovers at Oriel Park, but it's newly promoted Limerick FC who sit top of the pile after the first gameweekfollowing their 5-1 win over Sligo Rovers.
This weekend, Bohemians travel to Shamrock Rovers with both sides looking for their first points of the season after opening day disappointments.
Harry Kenny watched his Bray Wanderers side get of to a flying start with victory away to St. Pat's and now welcome Finn Harps to the Carlisle Ground.
Both Derry City and Limerick City recorded heavy wins in their league openers and now the pair come face-to-face at Maginn Park on Friday night.
Cork City look to continue their perfect start to the season when they host Galway United at Turner's Cross. John Caulfield's side ran out 1-0 winners against Finn Harps in miserable conditions and will look to make it three wins on the bounce this season - factoring in their win over Dundalk in the Presidents Cup.
Drogheda aim to build on last week's victory in Galway as they host St Pat's, while Sligo host Dundalk at the Showgrounds.
Drogheda will be without Killian Brennan this week, who has been ruled out for up to 10 weeks with a broken collarbone.
You can catch up with all this week's action from the League of Ireland in this week's Newstalk's SSE Airtricity League Podcast with Oisin Langan and Daniel Kelly.
Premier Division
Shamrock Rovers vs. Bohemians (7.30pm)
Bray Wanderers vs. Finn Harps, Carlisle Grounds (7.45pm)
Derry City vs. Limerick FC, Maginn Park (7.45pm)
Cork City vs. Galway United FC, Turner's Cross (7.45pm)
Drogheda United vs. St Patrick's Athletic, United Park (7.45pm)
Sligo Rovers vs. Dundalk, The Showgrounds (Saturday 4/3, 7.45pm)
First Division
UCD vs. Shelbourne, UCD Bowl (7.45pm)
Waterford FC vs. Cabinteely, Regional Sports Centre (7.45pm)
Wexford FC vs. Athlone Town, Ferrycarrig Park (8pm)
Longford Town vs. Cobh Ramblers, City Calling Stadium (Saturday 4/3, 7.30pm)
Download the brand new OffTheBall App in the Play Store & App Store right now! We've got you covered!
Subscribe to OffTheBall's YouTube channel for more videos, like us on Facebook or follow us on Twitter for the latest sporting news and content.